This will be the 2nd time the sides have faced it each other this season, as Cardiff won at Stadiwm Zip World in the Specsavers Cup back in September.
Good results against Pontypridd and Llanelli have pushed RGC into 3rd place, but this is the toughest test of the season so far.
Beau Williams and the players know they will need to hit the top level in performance "This weekend is going to be a big challenge for us coming up against a strong Cardiff side. Obviously losing to them in the first round of the cup is still pretty raw for us so we will be looking to get one back. We have taken a lot of confidence from our last two performances but we know we will need to step up another level if we want to get the win this weekend"
Cardiff sit top of the table, with 4 wins from 4 so far. picking up a win in front of the tv cameras last Friday against Carmarthen Quins.